Speeding up drug discovery for brain diseases

Whitehead Institute team finds drugs that activate a key brain gene; initial tests in cells and mice show promise for rare, untreatable neurodevelopmental disorder. Source: [ Nicole Davis  | MIT News Office, July 31, 2019] A research team led by Whitehead Institute scientists has identified 30 distinct chemical compounds — […]

How we tune out distractions

Source: [Anne Trafton | MIT News Office, June 12, 2019] Neuroscientists trace a brain circuit that filters unwanted sensory input. Imagine trying to focus on a friend’s voice at a noisy party, or blocking out the phone conversation of the person sitting next to you on the bus while you […]

Monkeys with autism mutation show condition’s key traits

Source: [Spectrum, Jessica Wright | June 12, 2019] Researchers have engineered two generations of monkeys with mutations in SHANK3, a top autism gene. The first generation shows traits reminiscent of the condition, according to a study published today in Nature1. The researchers are the first to engineer monkeys using the gene-editing tool CRISPR and […]

Neuroscientists reverse some behavioral symptoms of Williams Syndrome

Source: [Anne Trafton | MIT News Office, April 22, 2019] Mouse study yields insights into the rare condition, may shed light on other neurological disorders. Williams Syndrome, a rare neurodevelopmental disorder that affects about 1 in 10,000 babies born in the United States, produces a range of symptoms including cognitive […]