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SCSB Colloquium Series – Randall Carpenter, M.D.

March 21, 2018 | 10:00 am - 11:00 am

Randall Carpenter, MD, Co-Founder, President and CEO Seaside Therapeutics..photo by www.mckeephotography.com..For use and publication by Seaside Therapeutic and editorial publications…For more information about the photograph, mckeephotography.com, matt@mckeephotography.com.617-910-9314

Wednesday, March 21, 2018
Time: 4:00 pm-5:00 pm, followed by reception . NEW TIME: 10:00 am-11:00 am
Speaker: Randall L. Carpenter, M.D.
Affiliation: Chief Scientific Officer, Rett Syndrome Research Trust; Research Affiliate, Picower Institute for Learning and Memory

Host: Mark Bear, Ph.D.

Talk title: Development of Targeted Therapeutics for Autism Spectrum Disorders.
 Twelve years ago, I co-founded Seaside Therapeutics ​with an MIT professor based upon a strong sense of optimism that substantial progress would soon be realized in treatment of neurodevelopmental disorders. A new era of molecular genetics and neurobiology suggested that genetic diagnoses need not equate to permanent mental disability, but can actually provide insights toward disease-altering treatments. A number of highly penetrant genetic mutations had been discovered and reproduced in animal models. ​novel therapeutics targeting the underlying pathophysiology were ​being ​validated in these animal models and preliminary human trials ​were demonstrat​ing​ promising efficacy.  However, ​subsequent larger definitive trials failed to demonstrate convincing therapeutic benefit. This lecture will address how these failures are informing therapeutic discovery and development with a particular focus on ​the ​R​ett S​yndrome ​R​esearch ​T​rust​’s ​R​oadmap ​to a Cure for Rett Syndrome. ​

[Video of the talk]


March 21, 2018
10:00 am - 11:00 am
Event Category:


Singleton Auditorium, Bldg. 46, Room 3002
43 Vassar Street
Cambridge, MA 02139 United States
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Simons Center for the Social Brain