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SCSB Colloquium Series: Maiken Nedergaard, M.D., Ph.D.

May 11, 2016 | 4:00 pm - 5:00 pm

 

University of Rochester Medical Center researcher Maiken Nedergaard is pictured in Flaum Atrium January 17, 2014. // photo by J. Adam Fenster / University of Rochester

University of Rochester Medical Center researcher Maiken Nedergaard is pictured in Flaum Atrium January 17, 2014. // photo by J. Adam Fenster / University of Rochester

Date: Wednesday, May 11, 2016
Time: 4:00 pm-5:00 pm, followed by reception
Speaker: Maiken Nedergaard, M.D., Ph.D.

Affiliation: Professor/Co-Director, University of Rochester/University of Copenhagen
Host: Mriganka Sur, Ph.D., FRS

Talk title: Ionostatic control of the sleep-wake cycle

 Abstract: The concerted release of neuromodulators, including norepinephrine, acetylcholine, histamine, dopamine, and orexin mediates arousal. All of these neuromodulators individually alter the membrane properties, spiking activity, and intracellular signaling pathways of subpopulations of neurons and glia, but how they implement the striking stereotypic patterns of EEG activity characterizing wakefulness versus sleep is not understood. We have in recent work found astrocytes play an unexpected important role in modulating the state of brain activity. In response to neuromodulators, astrocytes control the extracellular ion concentrations. In turn,  the  changes in extracellular K+, Ca2+, and Mg2+ appears to play a crucial role in shaping the EEG activity characteristic of  the sleep-wake cycle.

Details

Date:
May 11, 2016
Time:
4:00 pm - 5:00 pm
Event Category:

Venue

Singleton Auditorium, Bldg. 46, Room 3002
43 Vassar Street
Cambridge, MA 02139 United States
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Phone
617-324-7757

Organizer

Simons Center for the Social Brain