Loading Events

« All Events

  • This event has passed.

SCSB Colloquium Series – Carlos Portera-Cailliau, M.D., Ph.D.

September 16, 2020 | 4:00 pm - 5:00 pm

Date: Wednesday, September 16, 2020
Location: Zoom Webinar – Registration Required
Register in advance for this webinar: click here  
* After registering, you will receive a confirmation email containing information on how to join the webinar.

Speaker: Carlos Portera-Cailliau, M.D., Ph.D.
Professor of Neurology & Neurobiology, David Geffen School of Medicine, University of California, Los Angeles
Host: Dr. Elly Nedivi

Talk title: Interneuron dysfunction in the fragile X mouse model of autism

Abstract: To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we have adopted a symptom-to-circuit approach in theFmr1-/- mouse model of Fragile X syndrome (FXS).  Using a ‘go/no-go’ visual discrimination task and in vivo 2-photon calcium imaging, we find that impaired visual discrimination in Fmr1-/- mice correlates with marked deficits in orientation tuning of principal neurons in primary visual cortex, and a decrease in the activity of parvalbumin (PV) interneurons.  Restoring visually evoked activity in PV cells in Fmr1-/- mice with a chemogenetic (DREADD) strategy was sufficient to rescue their behavioral performance.  Strikingly, human subjects with FXS exhibit similar impairments in visual discrimination as Fmr1-/- mice.  These results suggest that manipulating inhibition may help sensory processing in FXS. More recently, we find that task performance of Fmr1-/- mice is impaired in the presence of visual or auditory distractors, suggesting that sensory hyperarousal may affect perceptual learning in autism, a problem we link to dysfunction of VIP interneurons.


September 16, 2020
4:00 pm - 5:00 pm
Event Category:


Zoom Webinar


Simons Center for the Social Brain