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SCSB Colloquium Series: Paola Arlotta, Ph.D.
October 14, 2015 | 4:00 pm - 5:00 pm
Date: Wednesday, October 14, 2015
Time: 4:00pm-5:00pm, followed by reception
Speaker: Paola Arlotta, Ph.D.
Affiliation: Professor of Stem Cell and Regenerative Biology, Harvard University
Talk Title: Development and Reprogramming of Neuronal Diversity in the Neocortex
Abstract: The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by distinct traits that are developmentally acquired under the control of several neuron subtype-specific and pan-neuronal genes. In my lecture I will cover some of our work aimed at understanding the principles governing the establishment of excitatory pyramidal neuron diversity in the cerebral cortex, and highlight the capacity of pyramidal neurons to postmitotically reprogram class-specific traits in vivo. Finally, I will propose a model for a role of pyramidal neuron diversity in controlling the behavior of other cell types, focusing on communication with oligodendrocytes and neuronal subtype-specific myelination in the cortex.