SCSB News

New research on a cytokine called IL-17 adds to growing evidence that immune molecules can influence behavior during illness. Source: [Anne Trafton | MIT News, April 7, 2025] Immune molecules called cytokines play important roles in the body’s defense against infection, helping to control inflammation and coordinating the responses of other immune […]

Molecules that fight infection also act on the brain, inducing ...

Associate Professor Evelina Fedorenko is working to decipher the internal structure and functions of the brain’s language-processing machinery. Source: Anne Trafton | MIT News | April 2, 2025 As a young girl growing up in the former Soviet Union, Evelina Fedorenko PhD ’07 studied several languages, including English, as her mother hoped […]

Looking under the hood at the brain’s language system

Source: [Picower News | David Orenstein, February 18, 2025] New research adds evidence that learning a successful strategy for approaching a task doesn’t prevent further exploration, even if it reduces performance. Maybe it’s a life hack or a liability, or a little of both. A surprising result in a new […]

Even after learning the right idea, humans and animals still ...

Source: McGovern News | Julie Pryor, January 23, 2025]   The National Academy of Sciences (NAS) announced today that McGovern Investigator Evelina Fedorenko will receive a 2025 Troland Research Award for her groundbreaking contributions towards understanding the language network in the human brain. The Troland Research Award is given annually to recognize unusual achievement by early-career […]

Evelina Fedorenko receives Troland Award from National Academy of Sciences

Source: [Picower News, David Orenstein | November 21, 2024] At a symposium of the Simons Center for the Social Brain, six speakers described a diversity of recently launched studies aimed at improving understanding of the autistic brain. From studies of the connections between neurons, to interactions between the nervous and […]

New autism research projects represent a broad range of approaches ...

System developed by MIT and Open Ephys team provides a fast, light, standardized means for combining multiple instruments with minimal hindrance of lab mouse mobility. [Source: Picower News | November 13, 2024] Individual technologies for recording and controlling neural activity in the brains of research mice have each advanced rapidly […]

Open technology platform enables new versatility for neuroscience research with ...

The Simons Foundation is pleased to announce the latest recipients of its prestigious independence awards. The 13 talented early-career scientists will receive support as they transition from mentored training to independent research positions. Each fellow will receive up to two years of postdoctoral support with an annual salary of $85,000, plus […]

Chenjie Shen, former Simons Center Postdoctoral fellow, among 13 Recipients ...

Like many big ideas, the Simons Center for the Social Brain started with conversation. In 2003, Jim and Marilyn Simons approached leaders at MIT looking for scientists studying autism. At the time, Mriganka Sur was chair of MIT’s department of brain and cognitive sciences, so he gathered a crew of scientists who, […]

MIT Center Improves Understanding of Autism and the Social Brain

Source: [Anne Trafton | MIT News | July 15, 2024] Propofol, a drug commonly used for general anesthesia, derails the brain’s normal balance between stability and excitability. There are many drugs that anesthesiologists can use to induce unconsciousness in patients. Exactly how these drugs cause the brain to lose consciousness has been […]

Study reveals how an anesthesia drug induces unconsciousness

Drawing on evidence from neurobiology, cognitive science, and corpus linguistics, MIT researchers make the case that language is a tool for communication, not for thought. Source: [Jennifer Michalowski | McGovern Institute for Brain Research | July 3, 2024] Language is a defining feature of humanity, and for centuries, philosophers and scientists have […]

What is language for?

MIT scientists honored in each of the three Kavli Prize categories: neuroscience, nanoscience, and astrophysics, respectively. Source: [MIT News, School of Science | June 12, 2024] MIT faculty members Nancy Kanwisher, Robert Langer, and Sara Seager are among eight researchers worldwide to receive this year’s Kavli Prizes. A partnership among the […]

Nancy Kanwisher, Robert Langer, and Sara Seager named Kavli Prize ...

New research addresses a gap in understanding how ketamine’s impact on individual neurons leads to pervasive and profound changes in brain network function. Source: [David Orenstein, The Picower Institute for Learning and Memory | June 4, 2024] Ketamine, a World Health Organization Essential Medicine, is widely used at varying doses […]

Study models how ketamine’s molecular action leads to its effects ...

The findings also reveal why identifying objects in black-and-white images is more difficult for individuals who were born blind and had their sight restored. Source: [Anne Trafton | MIT News | May 23, 2024] Even though the human visual system has sophisticated machinery for processing color, the brain has no problem recognizing […]

Study explains why the brain can robustly recognize images, even ...

An unmistakable takeaway from sessions of “UnrulyArt” is that all those “n’ts”—can’t, needn’t, shouldn’t, won’t—that can lead people to exclude children with disabilities or cognitive, social and behavioral impairments from creative activities aren’t really rules. They are merely assumptions and stigmas. When a session ends and the paint that was […]

Researchers and staff from MIT, including from the Simons Center ...

A new study co-led by Anna (Anya) Ivanova highlights how human neuroscience is paving the way for AI innovation — and what AI can teach us about ourselves. Source: [Georgia Tech News Center | March 19, 2024] One of the hallmarks of humanity is language, but now, powerful new artificial […]

Researchers Reveal Roadmap for AI Innovation in Brain and Language ...

An MIT study finds the brains of polyglots expend comparatively little effort when processing their native language. Source: [Anne Trafton, MIT News | March 10, 2024] A new study of people who speak many languages has found that there is something special about how the brain processes their native language. In […]

For people who speak many languages, there’s something special about ...

Team-based targeted projects, multi-mentor fellowships ensure that scientists studying social cognition, behavior, and autism integrate multiple perspectives and approaches to pressing questions. The secret to the success of MIT’s Simons Center for the Social Brain is in the name. With a founding philosophy of “collaboration and community” that has supported […]

Simons Center’s collaborative approach propels autism research, at MIT and ...

Across mammalian species, brain waves are slower in deep cortical layers, while superficial layers generate faster rhythms. Source [Anne Trafton, MIT News | January 18, 2024]  Throughout the brain’s cortex, neurons are arranged in six distinctive layers, which can be readily seen with a microscope. A team of MIT and […]

Study reveals a universal pattern of brain wave frequencies

Source [David Orenstein, Picower News | November 2, 2023] Picower Institute-based collaboration will study mechanisms that might enable peripheral immune cells to deliver a potentially therapeutic molecule to the brain. A new three-year research project, funded by the Simons Center for the Social Brain at MIT, posits that the immune system can […]

New grant to study possibility of an immunotherapy for autism

It’s not easy to parse young children’s words, but adults’ beliefs about what children want to communicate helps make it possible, a new study finds. Source: [Anne Trafton, MIT News | October 26, 2023] When babies first begin to talk, their vocabulary is very limited. Often one of the first […]

How adults understand what kids are saying

Source: [Spectrum News, Samantha Easter, Amy S.F. Lutz | October 24, 2023] Much attention has been paid recently to conflict within the autism community, between autistic adults and parents of profoundly autistic children — from a piece in Nature in May to a Spectrum article on the topic in January to a 2021 post on the “Today Show” blog about […]

Building bridges: Collaboration across the autism community

[Spectrum News, Maris Fessenden / September 26, 2023] A new lightweight device with a wisplike tether can record neural activity while mice jump, run and explore their environment. The open-source recording system, which its creators call ONIX, overcomes several of the limitations of previous systems and enables the rodents to move more […]

Lightweight system captures brain activity while mice jump

[MIT News | Maura R. O’Connor, Department of Brain and Cognitive Sciences | September 22, 2023] Over a decade ago, the neuroscientist Ev Fedorenko asked 48 English speakers to complete tasks like reading sentences, recalling information, solving math problems, and listening to music. As they did this, she scanned their […]

Re-imagining our theories of language

In a simple game that humans typically ace, mice learn the winning strategy, too, but refuse to commit to it, new research shows. [MIT News, David Orenstein | The Picower Institute for Learning and Memory | September 15, 2023] Neuroscience discoveries ranging from the nature of memory to treatments for disease have […]

Study decodes surprising approach mice take in learning

[Spectrum News, Peter Hess | March 23, 2023] Roughly 1 in 36 8-year-olds in the United States has autism, according to 2020 prevalence data released today by the Centers for Disease Control and Prevention (CDC). This figure represents a nearly 20 percent increase over the agency’s 2018 estimate of 1 in 44 and continues a decades-long […]

U.S. autism prevalence continues to rise as race and sex ...

[Picower News, David Orenstein | March 11, 2023] On March 10 the FDA approved Trofinetide, a drug based on the protein IGF-1, as the first drug available to treat Rett syndrome. The original research showing that IGF-1 could treat Rett syndrome was published by MIT in 2009. Rett syndrome is a […]

3 questions for Mriganka Sur: The basic research origin of ...

[Picower News, David Orenstein | March 10, 2023] When astrocyte function is disrupted, neurons in the brain’s motor cortex struggle to execute and refine motion, a new study in mice shows. From steering a car to swinging a tennis racket, we learn to execute all kinds of skilled movements during […]

Astrocyte cells critical for learning skilled movements

[Spectrum News, Shaena Montanari | March 2, 2023]   Margaret Brimble was a new professor in 1999 at the University of Auckland in New Zealand. The country was not exactly known as a hotbed of drug development, but Brimble was an optimist, a dedicated chemist and maybe even a bit […]

Debut drug for Rett syndrome at edge of approval

The Simons Center for the Social Brain (SCSB) at MIT, which celebrated its 10th anniversary last year, is pleased to announce its renewal with a $25M commitment from SFARI (the Simons Foundation Autism Research Initiative) for the next five years. SCSB will continue to focus on understanding the neural mechanisms […]

Simons Center for the Social Brain at MIT Renewed with ...

[UMass Amherst News | January 13, 2023] Assistant Professor Siyuan Rao of the UMass Amherst Biomedical Engineering Department has received a grant from the Air Force Office of Scientific Research, or AFOSR, to study “Non-invasive Cell-type-specific Magnetic Neural Modulation,” a next-generation technique for investigating neurological and psychiatric disorders, including depression, addiction, […]

Siyuan Rao, past Simons Fellow, Receives Prestigious AFOSR Young Investigator ...

Built on recent advances in machine learning, the model predicts how well individuals will produce and comprehend sentences. [Department of Brain and Cognitive Sciences | December 22, 2022] Cognitive scientists have long sought to understand what makes some sentences more difficult to comprehend than others. Any account of language comprehension, […]

Cognitive scientists develop new model explaining difficulty in language comprehension

[Spectrum News, Anila D’Mello | December 22, 2022] Listen to this story: How scientists can counteract their unwitting contributions to autism’s sex bias Audio Playe The amount of research dedicated to understanding autism has grown rapidly, with more than 50,000 papers about the condition published over the past decade alone. To […]

How scientists can counteract their unwitting contributions to autism’s sex ...

MIT researchers are discovering which parts of the brain are engaged when a person evaluates a computer program. [Steve Nadis | MIT CSAIL | December 21, 2022] Functional magnetic resonance imaging (fMRI), which measures changes in blood flow throughout the brain, has been used over the past couple of decades for a […]

This is your brain. This is your brain on code

Researchers discover that to sharpen its control over precise maneuvers, the brain uses comparisons between control signals — not the signals themselves. [Kevin Hartnett | Quanta Magazine | November 28, 2022] A mouse is running on a treadmill embedded in a virtual reality corridor. In its mind’s eye, it sees […]

The Brain Uses Calculus to Control Fast Movements

Large scale ECoG recording during social scene watching and social behaviors in marmosets Authors: *H. Xu, Y. Su, J. Sharma, W. Menegas, C. Trimmer, F. Liang, R. Landman, B. Zhang, M. Sur, R. Saxe, G. Feng, R. Desimone Abstract: Humans can understand social scenes at a glance. Abilities such as […]

SCSB @ the 2022 Society for Neuroscience Annual Meeting

Professors Mark Bear and Laura Kiessling ’83, along with Krishna Shenoy SM ’92, PhD ’95, David Tuveson ’87, and Martin Burke are among the newly elected members. On October 17, the National Academy of Medicine announced the election of 100 new members to join their esteemed ranks. MIT faculty members Laura […]

Five with MIT ties elected to the National Academy of ...

[Anne Trafton | MIT News Office | October 12, 2022] Gloria Choi’s studies of how the immune system and nervous system influence each other could yield new approaches to treating neurological disorders.   When Gloria Choi was making plans to launch her research lab at MIT, nearly 10 years ago, she thought […]

Building a bridge between neuroscience and immunology

[Emma Yasinski | Spectrum News | October 4, 2022] The Children’s Communication Checklist 2 (CCC-2) could help identify children with social-pragmatic communication difficulties, a new study has found. Although few children meet the diagnostic criteria for social (pragmatic) communication disorder (SCD) on its own, many with autism or other types of language problems also […]

Social-pragmatic difficulties common with autism, other diagnoses

Neurons derived from the cells of a person with fragile X syndrome develop atypically when transplanted into a mouse’s brain, a new study has found. Some of the differences replicate those seen in the brains of people with fragile X syndrome. Researchers have struggled to create mice that accurately model the condition, […]

Fragile X neurons develop atypically in chimeric mice

[Peter Hess | Spectrum News | September 14, 2022] A large mutation that leads to fragile X syndrome in people does not set off the same genetic cascade in mice, a new study shows. The work highlights the limitations of using mice to model the condition and the need to explore other model animals, […]

Largest-yet fragile X mutation in mice confirms model’s shortcomings

A commonly used screening test creates a gender gap that may hinder diagnosis and treatment for women and girls. [Anne Trafton | MIT News Office | September 8, 2022] In recent years, researchers who study autism have made an effort to include more women and girls in their studies. However, despite these […]

Studies of autism tend to exclude women, researchers find

Using organoids to model early development, researchers used an emerging microscopy technology to see that new neurons struggled to reach their developmental destination. [David Orenstein | Picower Institute for Learning and Memory | August 3, 2022] Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT […]

Advanced imaging reveals mired migration of neurons in Rett syndrome ...

To ensure a quick halt, brain circuit architecture avoids a slow process of integration in favor of quicker differentiation, study finds. [David Orenstein | Picower Institute for Learning and Memory | July 28, 2022] Your new apartment is just a couple of blocks down the street from the bus stop, but today […]

Sprint then stop? The brain is wired for the math ...

Studying speakers of 45 languages, neuroscientists found similar patterns of brain activation and language selectivity. [Anne Trafton | MIT News Office | July 18, 2022] Over several decades, neuroscientists have created a well-defined map of the brain’s “language network,” or the regions of the brain that are specialized for processing language. Found […]

Whether speaking Turkish or Norwegian, the brain’s language network looks ...

[Leah Campbell | Department of Brain and Cognitive Sciences | June 21, 2022] A team of cognitive scientists and doctors finds that patients with aphasia use different cognitive tools to compensate for language deficits. Bruce Willis’s recent announcement that he was retiring from acting brought widespread public attention to the neurological condition […]

Study illuminates trade-off between complex words and complex sentences

[Anne Trafton | MIT News | June 1, 2022] Unexpected outcomes trigger release of noradrenaline, which helps the brain focus its attention and learn from the event. When your brain needs you to pay attention to something important, one way it can do that is to send out a burst of noradrenaline, […]

How the brain responds to surprising events

Source: [Anne Trafton | MIT News Office, May 25, 2022] Modeling study suggests that the muffled environment in utero primes the brain’s ability to interpret some types of sound. Inside the womb, fetuses can begin to hear some sounds around 20 weeks of gestation. However, the input they are exposed to is […]

Early sound exposure in the womb shapes the auditory system

Source: [Jason Sparapani | Department of Materials Science and Engineering | MIT News | May 13, 2022] Professor Polina Anikeeva’s innovation in the treatment of neurological disorders highlights the interdisciplinary nature of her field. A pivotal moment in Polina Anikeeva’s career was when she looked at an MRI scan of Parkinson’s disease […]

Is it neuroscience? Chemistry? Art? Wulff Lecture shows versatility, diversity ...

Source: [David Orenstein | Picower Institute for Learning and Memory | May 2, 2022] Innovative brain-wide mapping study shows that an “engram,” the ensemble of neurons encoding a memory, is widely distributed and includes regions not previously realized. A new study by scientists at The Picower Institute for Learning and Memory at […]

A single memory is stored across many connected brain regions